PUBLICATIONS
Ketosis ameliorates renal cyst growth in polycystic kidney disease
Jacob A Torres, Samantha Kruger, Caroline Broderick, Tselmeg Amarlkhagva, Shagun Agrawal, John R Dodam, Michal Mrug, Leslie A Lyons, Thomas Weimbs. Cell Metabolism. Published October 17, 2019 https://doi.org/10.1016/j.cmet.2019.09.012.
Crystal deposition triggers tubule dilation that accelerates cystogenesis in polycystic kidney disease
Jacob A. Torres, Mina Rezaei, Caroline Broderick, Louis Lin, Xiaofang Wang, Bernd Hoppe, Benjamin D. Cowley, Jr., Vincenzo Savica, Vicente E. Torres, Saeed Khan, Ross P. Holmes, Michal Mrug and Thomas Weimbs. Journal of Clinical Investigation. Published July 30, 2019. https://doi.org/10.1172/JCI128503.
Trigger Warning: How Modern Diet, Lifestyle, and Environment Pull the Trigger on Autosomal Dominant Polycystic Kidney Disease Progression
Melina Messing, Jacob A. Torres, Nicholas Holznecht, Thomas Weimbs. Nutrients 16: 3281, 2024. doi: 10.3390/nu16193281.
β-Hydroxybutyrate Recapitulates the Beneficial Effects of Ketogenic Metabolic Therapy in Polycystic Kidney
Disease
Jacob A. Torres, Nickolas Holznecht, David A. Asplund, Bradley C. Kroes, Tselmeg Amarlkhagva, Matthias M. Haeffner, Elizabeth H. Sharpe, Stella Koestner, Brina Aceves, Margaret Schimmel, Muthusamy Thangaraju and Thomas Weimbs.’” iScience, August 20, 2024, 110773.
https://doi.org/10.1016/j.isci.2024.110773.
A Combination of β-Hydroxybutyrate and Citrate Ameliorates Disease Progression in a Rat Model of Polycystic Kidney Disease
Jacob A. Torres, Nickolas Holznecht, David A. Asplund, Tselmeg Amarlkhagva, Bradley Kroes, Juliette Rebello, Shagun Agrawal, and Thomas Weimbs. American Journal of Physiology-Renal Physiology, December 14, 2023. “https://doi.org/10.1152/ajprenal.00205.2023.
Feasibility and impact of ketogenic dietary interventions in polycystic kidney disease: KETO-ADPKD—a randomized controlled trial
Sadrija Cukoski, Christoph Heinrich Lindemann, Sita Arjune, Polina Todorova, Theresa Brecht, Adrian Kühn, Simon Oehm, Sebastian Strubl, Ingrid Becker, Ulrike Kämmerer, Jacob Alexander Torres, Franziska Meyer, Thomas Schömig, Nils Große Hokamp, Florian Siedek, Ingo Gottschalk, Thomas Benzing, Johannes Schmidt, Philipp Antczak, Thomas Weimbs, Franziska Grundmann, Roman-Ulrich Müller. Cell Reports Medicine, Published November 6, 2023 https://doi.org/10.1016/j.xcrm.2023.101283
Ren.Nu, a Dietary Program for Individuals with Autosomal-Dominant Polycystic Kidney Disease Implementing a Sustainable, Plant-Focused, Kidney-Safe, Ketogenic Approach with Avoidance of Renal Stressors
Bruen, Diana M., Jacob J. Kingaard, Meg Munits, Clarissa S. Paimanta, Jacob A. Torres, Jessianna Saville, and Thomas Weimbs. Kidney and Dialysis 2, no. 2: 183-203. Published April 13, 2022 https://doi.org/10.3390/kidneydial2020020
Ketogenic Dietary Interventions in Autosomal-Dominant Polycystic Kidney Disease (ADPKD)– A Retrospective Case Series Study: First Insights into Feasibility, Safety and Effects
Strubl, Sebastian, Simon Oehm, Jacob A Torres, Franziska Grundmann, Jazmine Haratani, Morgan Decker, Sabrina Vuong, et al. Clinical Kidney Journal, no. sfab162. Published September 13, 2021. https://doi.org/10.1093/ckj/sfab162.
STAT signaling in polycystic kidney disease
Strubl S, Torres JA, Spindt AK, Pellegrini H, Liebau MC, Weimbs T. Cellular Signaling. Published online April 20, 2020 doi:10.1016/j.cellsig.2020.109639
Identification of Targets of Interleukin-13 and Signal Transducer and Activator of Transcription-6 (STAT6) Signaling in Polycystic Kidney Disease
OIsan EE, West JD, Torres JA, Doerr N, Weimbs T. American Journal of Physiology-Renal Physiology, 2018 March 7
https://doi.org/10.1152/ajprenal.00346.2017
Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease
Thomas Weimbs, Jonathan Shillingford, Jacob A. Torres, Samantha Kruger, Bryan Bourgeois.
Clinical Kidney Journal, Volume 11, Issue suppl_1, 1 December 2018, Pages i27-38, https://doi.org/10.1093/ckj/sfy089
Jacob A Torres, Samantha Kruger, Caroline Broderick, Tselmeg Amarlkhagva, Shagun Agrawal, John R Dodam, Michal Mrug, Leslie A Lyons, Thomas Weimbs. Cell Metabolism. Published October 17, 2019 https://doi.org/10.1016/j.cmet.2019.09.012.
Crystal deposition triggers tubule dilation that accelerates cystogenesis in polycystic kidney disease
Jacob A. Torres, Mina Rezaei, Caroline Broderick, Louis Lin, Xiaofang Wang, Bernd Hoppe, Benjamin D. Cowley, Jr., Vincenzo Savica, Vicente E. Torres, Saeed Khan, Ross P. Holmes, Michal Mrug and Thomas Weimbs. Journal of Clinical Investigation. Published July 30, 2019. https://doi.org/10.1172/JCI128503.
Trigger Warning: How Modern Diet, Lifestyle, and Environment Pull the Trigger on Autosomal Dominant Polycystic Kidney Disease Progression
Melina Messing, Jacob A. Torres, Nicholas Holznecht, Thomas Weimbs. Nutrients 16: 3281, 2024. doi: 10.3390/nu16193281.
β-Hydroxybutyrate Recapitulates the Beneficial Effects of Ketogenic Metabolic Therapy in Polycystic Kidney
Disease
Jacob A. Torres, Nickolas Holznecht, David A. Asplund, Bradley C. Kroes, Tselmeg Amarlkhagva, Matthias M. Haeffner, Elizabeth H. Sharpe, Stella Koestner, Brina Aceves, Margaret Schimmel, Muthusamy Thangaraju and Thomas Weimbs.’” iScience, August 20, 2024, 110773.
https://doi.org/10.1016/j.isci.2024.110773.
A Combination of β-Hydroxybutyrate and Citrate Ameliorates Disease Progression in a Rat Model of Polycystic Kidney Disease
Jacob A. Torres, Nickolas Holznecht, David A. Asplund, Tselmeg Amarlkhagva, Bradley Kroes, Juliette Rebello, Shagun Agrawal, and Thomas Weimbs. American Journal of Physiology-Renal Physiology, December 14, 2023. “https://doi.org/10.1152/ajprenal.00205.2023.
Feasibility and impact of ketogenic dietary interventions in polycystic kidney disease: KETO-ADPKD—a randomized controlled trial
Sadrija Cukoski, Christoph Heinrich Lindemann, Sita Arjune, Polina Todorova, Theresa Brecht, Adrian Kühn, Simon Oehm, Sebastian Strubl, Ingrid Becker, Ulrike Kämmerer, Jacob Alexander Torres, Franziska Meyer, Thomas Schömig, Nils Große Hokamp, Florian Siedek, Ingo Gottschalk, Thomas Benzing, Johannes Schmidt, Philipp Antczak, Thomas Weimbs, Franziska Grundmann, Roman-Ulrich Müller. Cell Reports Medicine, Published November 6, 2023 https://doi.org/10.1016/j.xcrm.2023.101283
Ren.Nu, a Dietary Program for Individuals with Autosomal-Dominant Polycystic Kidney Disease Implementing a Sustainable, Plant-Focused, Kidney-Safe, Ketogenic Approach with Avoidance of Renal Stressors
Bruen, Diana M., Jacob J. Kingaard, Meg Munits, Clarissa S. Paimanta, Jacob A. Torres, Jessianna Saville, and Thomas Weimbs. Kidney and Dialysis 2, no. 2: 183-203. Published April 13, 2022 https://doi.org/10.3390/kidneydial2020020
Ketogenic Dietary Interventions in Autosomal-Dominant Polycystic Kidney Disease (ADPKD)– A Retrospective Case Series Study: First Insights into Feasibility, Safety and Effects
Strubl, Sebastian, Simon Oehm, Jacob A Torres, Franziska Grundmann, Jazmine Haratani, Morgan Decker, Sabrina Vuong, et al. Clinical Kidney Journal, no. sfab162. Published September 13, 2021. https://doi.org/10.1093/ckj/sfab162.
STAT signaling in polycystic kidney disease
Strubl S, Torres JA, Spindt AK, Pellegrini H, Liebau MC, Weimbs T. Cellular Signaling. Published online April 20, 2020 doi:10.1016/j.cellsig.2020.109639
Identification of Targets of Interleukin-13 and Signal Transducer and Activator of Transcription-6 (STAT6) Signaling in Polycystic Kidney Disease
OIsan EE, West JD, Torres JA, Doerr N, Weimbs T. American Journal of Physiology-Renal Physiology, 2018 March 7
https://doi.org/10.1152/ajprenal.00346.2017
Emerging targeted strategies for the treatment of autosomal dominant polycystic kidney disease
Thomas Weimbs, Jonathan Shillingford, Jacob A. Torres, Samantha Kruger, Bryan Bourgeois.
Clinical Kidney Journal, Volume 11, Issue suppl_1, 1 December 2018, Pages i27-38, https://doi.org/10.1093/ckj/sfy089